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Education Library

Publication: Stroke (online ahead of print), Feb 9, 2026.

What it is:
- Prospective, single-arm, national multi-center observational study of consecutive intracranial endovascular cases using the MicroAngioscope as an adjunct.

Study focus:
- Primary: safety (prospective collection of procedural complications).
- Secondary: successful visualization of vasculature and deployed implants.

Reported case mix (N=31):
- Carotid stenting: 9
- Flow diversion: 6
- Transverse sinus stenting: 11
- Aneurysm intrasaccular flow-disruption: 2
- Aneurysm treatment with stent-assisted coiling: 1
- Mechanical thrombectomy: 2

Reported outcomes / value-add:
- Successful delivery to the location of interest with direct live visualization of vessel condition and/or deployed implants.
- No angiographic vessel injury reported.
- All cases reported as completed without complications; all patients neurologically unchanged post-procedure.
- Described utility for carotid web diagnosis, assessing immediate wall apposition after deployment (flow diverter and venous stent), and assessing strut coverage in follow-up.

AHA/ASA Stroke: Visualization of the Human Intracranial Vasculature and Intracranial Implants Using Microangioscopy

Journal Article

Publication: Stroke: Vascular and Interventional Neurology 4(5):e001340 (July 7, 2024).

Study outline:
- Rabbit carotid model with shielded vs non-shielded flow diverters and different antiplatelet regimens.
- Follow-up at 30 days with angiography and microangioscopy; independent evaluators compared imaging against histopathology.

Reported findings:
- In aspirin and dual antiplatelet therapy groups: no significant observed differences between devices for thrombosis, stenosis, malapposition, or neoepithelialization.
- Increased thrombus formation reported in the group without periprocedural antiplatelet therapy.
- Microangioscopy-based neointimal thickness measurements correlated with histology (reported r≈0.72; P≈0.016).

Why it matters:
- Supports microangioscopy as a potential adjunct to angiography for device follow-up and endoluminal assessment in flow diversion models.

SVIN: Preclinical Direct Endoluminal Assessment of Endothelialization After Flow Diversion With Microangioscopy

Journal Article

SLICE Worldwide: Live Demo

Video

Publication: AJNR American Journal of Neuroradiology 42(2):347-353 (2021). Epub Dec 24, 2020.

What it covers:
- Evaluated iterative microangioscope prototypes for neurodiagnostics and neurointerventions in live animal and human cadaveric models.
- Diagnostic assessments included clot identification/differentiation, plaque identification, vessel wall injury inspection, and stent apposition assessment.
- Interventions included angioscope-assisted stent-retriever thrombectomy, clot aspiration, and coil embolization.

Reported evaluator scoring (5-point scales):
- Imaging quality mean scores ranged approximately from 3.0 (clot identification) up to 4.7 (Pipeline follow-up).
- Clinical utility mean scores ranged approximately from 3.0 (aspiration thrombectomy) up to 4.7 (coil embolization and WEB device aneurysm treatment).

AJNR: Applications of a Novel Microangioscope for Neuroendovascular Intervention

Journal Article

Publication: Journal of NeuroInterventional Surgery 16(Suppl 1):A267.1-A267 (July 2024).
Conference: SNIS 21st Annual Meeting Abstracts.

Reported highlights:
- Technology: coherent fiber bundle-based MicroAngioscope designed to be sized and flexible for intracranial use.
- Early experience: first 8 cases reported across multiple centers in Canada (special authorization described).
- Use cases included carotid web stenting, flow diverter aneurysm treatment (with or without adjunctive coiling), venous sinus stenting, intrasaccular embolization of a venous diverticulum, and delayed assessment of a previously treated pseudoaneurysm.
- Reported outcome: device delivered and visualization achieved in all cases, with no reported dissection or perforation; cases completed without reported thromboembolic events and patients neurologically unchanged.

SNIS Late Breaking: Visualization of the human intracranial vasculature and intracranial implants using microangioscopy

Abstract, Video

Publication: Journal of NeuroInterventional Surgery 11(10):1036-1039 (Oct 2019). Epub Mar 16, 2019.

What it covers:
- Design evolution and key engineering choices for a microangioscope compatible with neurovascular anatomy.
- Preclinical demonstration of intravascular imaging performance in an in vivo porcine model.
- Example neurointerventional applications enabled by direct endoluminal visualization (as an adjunct to conventional imaging).

JNIS: A new set of eyes: development of a novel microangioscope for neurointerventional surgery

Journal Article

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