SVIN: Preclinical Direct Endoluminal Assessment of Endothelialization After Flow Diversion With Microangioscopy

Rabbit model study using microangioscopy plus angiography to evaluate flow diverter endothelialization and related findings, comparing shielded vs non-shielded flow diverters and validating microangioscopy measurements against histopathology.

Publication: Stroke: Vascular and Interventional Neurology 4(5):e001340 (July 7, 2024).

Study outline:
- Rabbit carotid model with shielded vs non-shielded flow diverters and different antiplatelet regimens.
- Follow-up at 30 days with angiography and microangioscopy; independent evaluators compared imaging against histopathology.

Reported findings:
- In aspirin and dual antiplatelet therapy groups: no significant observed differences between devices for thrombosis, stenosis, malapposition, or neoepithelialization.
- Increased thrombus formation reported in the group without periprocedural antiplatelet therapy.
- Microangioscopy-based neointimal thickness measurements correlated with histology (reported r≈0.72; P≈0.016).

Why it matters:
- Supports microangioscopy as a potential adjunct to angiography for device follow-up and endoluminal assessment in flow diversion models.

Peer-reviewed, Preclinical, Animal model, Flow diversion

Cerebral aneurysm management, Flow diversion, Endothelialization, In-stent thrombosis, In-stent stenosis, Neointimal thickness

https://www.ahajournals.org/doi/10.1161/SVIN.124.001340