AHA/ASA Stroke: Visualization of the Human Intracranial Vasculature and Intracranial Implants Using Microangioscopy

First-in-human prospective multicenter observational study (31 cases) demonstrating successful delivery and real-time endoluminal visualization with the MicroAngioscope as an adjunct to angiography, with no angiographic vessel injury or procedural complications reported.

Publication: Stroke (online ahead of print), Feb 9, 2026.

What it is:
- Prospective, single-arm, national multi-center observational study of consecutive intracranial endovascular cases using the MicroAngioscope as an adjunct.

Study focus:
- Primary: safety (prospective collection of procedural complications).
- Secondary: successful visualization of vasculature and deployed implants.

Reported case mix (N=31):
- Carotid stenting: 9
- Flow diversion: 6
- Transverse sinus stenting: 11
- Aneurysm intrasaccular flow-disruption: 2
- Aneurysm treatment with stent-assisted coiling: 1
- Mechanical thrombectomy: 2

Reported outcomes / value-add:
- Successful delivery to the location of interest with direct live visualization of vessel condition and/or deployed implants.
- No angiographic vessel injury reported.
- All cases reported as completed without complications; all patients neurologically unchanged post-procedure.
- Described utility for carotid web diagnosis, assessing immediate wall apposition after deployment (flow diverter and venous stent), and assessing strut coverage in follow-up.

Peer-reviewed, First-in-human, Prospective, Multicenter, Observational

Neurointervention, Intracranial vasculature, Carotid stenting, Flow diversion, Venous sinus stenting, Aneurysm treatment, Mechanical thrombectomy, Carotid web

https://www.ahajournals.org/doi/10.1161/STROKEAHA.125.052675